Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling
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Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling
Insulin is secreted as discrete insulin secretory bursts at ~5-min intervals into the hepatic portal vein, these pulses being attenuated early in the development of type 1 and type 2 diabetes mellitus (T2DM). Intraportal insulin infusions (pulsatile, constant, or reproducing that in T2DM) indicated that the pattern of pulsatile insulin secretion delivered via the portal vein is important for he...
متن کاملPulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans.
In health, insulin is secreted in discrete pulses into the portal vein, and the regulation of the rate of insulin secretion is accomplished by modulation of insulin pulse mass. Several lines of evidence suggest that the pattern of insulin delivery by the pancreas determines hepatic insulin clearance. In previous large animal studies, the amplitude of insulin pulses was related to the extent of ...
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Hepatic extraction of insulin was examined in anesthetized dogs before and after constant infusion of insulin (20 and 50 mU/min) with use of samples from the portal vein, mesenteric vein, left common hepatic vein, and the femoral artery. In 19 dogs, measurement of portal vein insulin concentration indicated an overall recovery of 110% of the insulin infused. The range varied from 9 to 303%, ind...
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Subcutaneous insulin administration in the diabetic patient causes peripheral hyperinsulinemia, which contributes to vascular disease, hyperlipidemia and coagulation abnormalities. In the non diabetic patient, insulin is released from the pancreas into the portal system. The majority of this endogenous insulin is taken up by the liver in the first pass so that portal insulin exceeds peripheral ...
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RATIONALE Adiponectin enhances insulin action and induces nitric oxide-dependent vasodilatation. Insulin delivery to muscle microcirculation and transendothelial transport are 2 discrete steps that limit insulin's action. We have shown that expansion of muscle microvascular surface area increases muscle insulin delivery and action. OBJECTIVE To examine whether adiponectin modulates muscle mic...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2012
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db11-1462